ABSTRACT
The national neonatal screening programme in the United Arab Emirates currently includes 16 disorders: congenital hypothyroidism, sickle-cell diseases, congenital adrenal hyperplasia, biotinidase deficiency and 12 amino acid, organic acid and fatty acid disorders. This paper reports data since the programme started in January 1995 up to December 2011 on the incidence of screened disorders and the molecular basis of positive screened cases. Screening used a combination of tandem mass spectrometry, molecular technologies and biochemical analysis. A total of 750 365 infants were screened and 717 babies saved from associated morbidity and/or mortality. The incidence of screened disorders were 1:1 873 for congenital hypothyroidism, 1:14 544 for phenylketonuria, 1:3 526 for amino acid, organic acid and fatty acid disorders, 1:9 030 for classical congenital adrenal hyperplasia, 1:8 300 for biotinidase deficiency, 1:2 384 for sickle-cell disease and 1:121 for sickle-cell traits. Coverage of neonatal screening in the population reached 95% in 2010
Subject(s)
Humans , Health Care Surveys , Infant, Newborn , Pilot Projects , Quality Assurance, Health Care , Health Care SurveysABSTRACT
In January 2002, a pilot programme of neonatal screening for sickle cell disease was launched in the United Arab Emirates [UAE] in 3 districts of Abu Dhabi emirate. This paper reports the incidence of sickle cell diseases, other haemoglobinopathies and haemoglobinopathy carriers over a 12-month period using high performance liquid chromatography as a primary screening method. The overall incidence of sickle cell disease among 22 200 screened neonates was 0.04% [0.07% for UAE citizens and 0.02% for non-UAE citizens]. The incidence of sickle cell trait was 1.1% overall [1.5% for UAE citizens and 0.8% for non-UAE citizens]. Universal neonatal screening for sickle cell haemoglobin at the national level should be considered
Subject(s)
Humans , Birth Rate , Chromatography, Liquid , Follow-Up Studies , Genetic Counseling , Hemoglobin C Disease/diagnosisABSTRACT
The National Congenital Anomalies Register is a population-based register covering all births in the United Arab Emirates. We evaluated the progress of the register and determined the prevalence of congenital anomalies [CAs] and associated maternal and neonatal risk factors. Total prevalence of CAs for 1999-2001 was 7.89/1000, 10.95/1000 and 7.92/1000 for live births, stillbirths and total births respectively. Rates were comparable to international rates for all districts except Dubai, Fujairah and Ras Al Khaimah. According to the International classification of diseases, the cardiovascular system was the most affected followed by CAs of chromosomal and the musculo-skeletal system. Birth defects were more common with older maternal age, gr and multiparity, male babies, low-birth-weight babies and premature babies
Subject(s)
Female , Humans , Male , Age Distribution , Birth Rate , Birth Weight , Chromosome Aberrations/statistics & numerical data , Consanguinity , Gestational AgeABSTRACT
The United Arab Emirates National Screening Programme for Congenital Hypothyroidism was established in January 1998. The programme measures neonatal thyroid-stimulating hormone [TSH] levels of blood samples collected on filter paper on day 5 by heel prick. The prevalence of raised TSH levels [> 5 microU/mL whole blood] during 1998 and 1999 was used to evaluate the degree of iodine-deficiency disorders [IDD] in the population in different regions. The ratio of TSH profile in the present study and goitre rate in schools in a 1994 study were discrepant, although there was good correlation between the ratio of TSH profile and urinary iodine. The prevalence of raised TSH levels was < 3% in the Emirates overall, which is normal, and IDD varied from mild to normal problems in different regions
Subject(s)
Adult , Child , Humans , Infant , Congenital Hypothyroidism , Goiter, Endemic/metabolism , Health Status Indicators , Dental Health Surveys , Incidence , Infant, Newborn , Morbidity , Sensitivity and SpecificityABSTRACT
To evaluate the United Arab Emirate National Newborn Screening Programme we compared coverage, timeliness of programme indicators [age at sampling, recall and treatment initiation, timing of specimen delivery and laboratory results] and specimen quality with international st and ards. Recall rate, sensitivity, specificity, positive predictive values and relative incidence rates for phenylketonuria [PKU] and congenital hypothyroidism [CH] were calculated. Investigations for hypothyroidism included thyroid function studies [T3, T4, fT4 and TSH], technetium-99m thyroid scan when possible and thyroglobulin and thyroid antibodies when indicated. PKU investigations included plasma amino acids and measurement of biopterin defects. In the 6 years before December 2000, 138,718 neonates were screened. Relative incidences for CH and for classic PKU were 1:1570 and 1:20,050 respectively
Subject(s)
Humans , Aftercare/standards , Age Factors , Amino Acids/blood , Biopterin/blood , Birth Rate , Congenital Hypothyroidism , Health Services Needs and Demand , Hypothyroidism/epidemiology , Infant, NewbornABSTRACT
This paper reports on health for all in the United Arab Emirates. The current situation in the country regarding health for all and primary health care is described as well as the progress that has been made in this area. The main primary health care programmes and future activities are outlined